The study of the effect of Ha-Rak extracts against the SARS-CoV-2 Delta variant

Abstract

The Coronavirus Disease 2019 (COVID-19) outbreak has had a profound impact on health, severely impacted and the global economic five roots remedy. This study aimed to evaluate the antiviral activity of herbal extracts from a five-root, which consists of five types of herbs: Chingchi, Ya-nang, Khonthaa, Arrowroot, and Chumphon Fig. The efficacy of the five-root remedy was tested using the plaque reduction neutralization assay in Vero cell lines to assess their effectiveness in inhibiting the Delta strain of SARS-CoV-2. The results indicated that the five-root formula extract exhibited a significant inhibitory effect on the Delta variant of SARS-CoV-2, with an average plaque reduction of 96.23% at the highest non-toxic concentration (10 mg/ml). These findings highlight the potential of Thai herbal extracts as antiviral agents against SARSCoV-2 and suggest their potential use in developing alternative herbal treatments for viral infections. Despite these promising results, further clinical studies are necessary to validate the efficacy and safety of the five-root herbal extract. Additionally, research should focus on understanding the molecular mechanisms of action and testing the efficacy of these extracts against other currently circulating viral strains.