Factors Relating to Post Discharge Persistence of Symptoms After Hospitalization Among Persons with Coronavirus Disease 2019

Authors

  • Montira Channarong Sichon Hospital, Nakhon Si Thammarat Province

Keywords:

long COVID, patients with COVID-19, post discharge, related factors

Abstract

The Coronavirus disease 2019 [COVID-19] pandemic caused the large number of people to become infected with COVID-19, many of whom continue to have COVID symptoms long after they have been discharged from the hospital, referred to as “long-term COVID” or simply “long COVID”. However, there has not been a study of the factors related to long COVID in Thailand.  This cross-sectional descriptive study aimed to study the factors that are related to and influence persisting symptoms of COVID in persons who were hospitalized with COVID-19 after being discharged from the hospital. Participants were 392 persons infected with COVID-19 who required hospitalization and had been discharged from the hospital for at least 3 months. They were systematically randomly recruited into the study. Data were collected using a questionnaire asking participants about the persistence of symptoms after having been discharged from the hospital after treatment for their COVID-19 infection. The questionnaire was developed by the researcher and validated by five experts who determined it had an item-objective congruence index between .60 and 1.0. Its reliability was calculated to be .99 calculated using Cronbach’s alpha coefficient. Data were analyzed using Chi-square tests and Odds Ratios (OR). The results revealed that age, occupation, preexisting medical conditions, and the severity of symptoms were statistically significantly (p < .05) related to long-term COVID symptoms. Factors statistically significantly influencing persisting symptoms after discharge from the hospital were being aged between 41 and 50 years old, being over 60 years of age, being a housewife, and having few symptoms. Being employed was a protecting factor against continuing post COVID symptoms. The results can be used to develop continuous care plan systems for patients after being discharged from hospitals and to plan for rehabilitation or urgent care to prevent long-term complications.

References

กรมการแพทย์. (2565). แนวทางเวชปฏิบัติ การวินิจฉัย ดูแลรักษา และป้องกันการติดเชื้อในโรงพยาบาล กรณีผู้ป่วยติดเชื้อไวรัสโคโรนา 2019 (COVID-19) สำหรับแพทย์และบุคลากรสาธารณสุข ฉบับปรับปรุง วันที่ 22 เมษายน พ.ศ. 2565. สืบค้นจาก https://covid19.dms.go.th/backend/Content/Content_FIle/Bandner_(Big)/Attach/25650422162121PM_CPG_COVID-19_n_v.22_20220422.pdf (dms.go.th)

อรุณ จิรวัฒน์กุล. (2551). ชีวสถิติสำหรับงานวิจัยทางวิทยาศาสตร์สุขภาพ (พิมพ์ครั้งที่ 3). ขอนแก่น: คลังนานาวิทยา.

Aiyegbusi, O. L., Hughes, S. E., Turner, G., Rivera, S. C., McMullan, C., Chandan, J. S., . . . Calvert., M. J. (2021). Symptoms, complication and management of long COVID: A review. Journal of Royal Society of Medicine, 114(9), 428-442. doi: 10.1177/01410768211032850

Health Data Center. (2565). กลุ่มรายงานมาตรฐาน: ประชากรจำแนกเพศกลุ่มอายุรายปี. สืบค้นจาก https://nrt.hdc.moph.go.th/hdc/main/index.php

Hossain, M. A., Hossain, K. M., Saunders, K., Uddin, Z., Walton, L. M., Raigangar, V., . . . Jahid, I. K. (2021). Prevalence of long covid symptoms in Bangadesh: A prospective inception cohort study of covid-19 survivors. BMJ Global Health, 6, e006838. doi: 10.1136/bmjgh-2021-006838

Jacobs, L. G., Gourna, P. E., Lesky-Di, B. D., Nyirenda, T., Friedman, T., Gupta, A., . . . Aschner, J.L. (2020). Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection. PLoS One, 15(12), e0243882. doi: 10.1371/journal.pone.0243882

Jones, R., Davis, A., Stanley, B., Julious, S., Ryan, D., Jackson, D. J., . . . Price, D. (2021). Risk predictors and symptom features of long COVID within a broad primary care patient population including both tested and untested patients. Pragmatic Observation Research, 12, 93-104. doi: 10.2147/POR.S316186

Kersten, J., Woft, A., Hoyo, L., Hull, E., Taduc, M., Andreb, S., . . . Bucket, D. (2022). Symptom burden correlates to impairment of diffusion capacity and exercise intolerance in long COVID patients. Scientific Report, 12(1), 8801. doi: 10.1038/s41598-022-12839-5

Michelen, M., Manoharan, L., Elkheir, N., Cheng, V., Dagens, A., Hastie, C., . . . Stavropoulou, C. (2021). Characterizing long Covid: A living systemic review. British Medical Journal Global Health, 6(9), e005427. doi: 10.1136/bmjgh-2021-005427

Mohamed, M. S., Moulin, T. C., & Schioth, H. B. (2021). Sex differences in COVID-19: The role of androgens in disease severity and progression. Endrocrine, 71(1), 3-8. doi: 10.1007/s12020-020-02536-6

Munblit, D., Bobkova, P., Spiridonova, E., Shikhaleva, A., Gamirova, A., Blyuss, O., . . . Butnaru, D. (2021). Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19. Clinical and Experimental Allergy, 51(9), 1107-1120. doi: 10.1111/cea.13997

National Institute for Health and Care Excellence. (2021). Rapid guideline: Managing the long-term effect of Covid-19. สืบค้นจาก http://www.nice.org.uk/gyidance/ng188

Nune, A., Durkowski, V., Titman, A., Gupta, L., Hadzhiivanov, M., Ahmed, A., . . . Sapkota, H. R. (2021). Incidence and risk factors of long COVID in the UK: A single-centre observation study. The Journal of the Royal College of Physicians of Edinburgh, 51(4), 338-343. doi: 10.4997/JRCPE.2021.405

Pelà, G., Goldoni, M., Solinas, E., Cavalli, C., Tagliaferri, S., Ranzieri, S., . . . Chetta, A. J. (2022). Sex-related differences in long-COVID-19 syndrome. Womens Health (Larchmt), 31(5), 620-630. doi: 10.1089/jwh.2021.0411

Razai, M. S., AI-Bedaery, R., Anand, L., Fitch, K., Okechukwu, H., Saraki, T. M., & Oakeshott, P. (2021). Patients’ experiences of “Long covid” in the community and recommendations for improving services: A quality improvement survey. Journal of Primary Care & Community Health, 12, doi: 10.1177/21501327211041846

Staffolani, S., Iencinella, V., Cimatti, M., & Tavio, M. (2022). Long COVID-19 syndrome as a fourth phase of SARS-CoV-2 infection. Le Infezioni in Medicina, 30(1), 22–29. doi: 10.53854/liim-3001-3

Tleyjeh, I. M., Saddik, B., AlSwaidan, N., AlAnazi, A., Ramakrishnan, R. K., Alhazmi, D., . . . Halwani, R. (2021). Prevalence and predictors of post-acute COVID-19 syndrome (PACS) after hospital discharge: A cohort study with 4 months median follow-up. PLoS One, 16(12), e0260568. doi: 10.1371/journal.pone.0260568

Townsend, L., Dowds, L., O’Brien, K., Sheill, G., Dyer, A. H., O’Kelly, B., . . . Bannan, C. (2021). Persistent poor health after COVID-19 is not association with respiratory complications or initial disease severity. Annal of the American Thoracic Society, 18(6), 997-1003. doi: 10.1513/AnnalsATS.202009-1175OC

Vimercati, L., Maria, L. D., Quarato, M., Caputi, A., Gesualdo, L., Migliore, G., . . . Tafuri, S. (2021). Association between long COVID and overweight/obesity. Journal of Clinical Medicine, 10, 4143. doi: 10.3390/jcm10184143

World Health Organization. (2021). WHO Coronavirus (COVID-19) Dashboard. สืบค้นจาก https://covid19.who.int/data

Whitaker, M., Elliott, J., Chadeau-Hyam, M., Riley, S., Darzi, A., & Cook, G. (2022). Persistent COVID-19 symptoms in a community study of 606,434 people in England. Nature Communication, 13(1), 1957. doi: 10.1038/s41467-022-29521-z

Yong, S. J. (2021). Long COVID or post-COVID-19 syndrome: Putative pathophysiology, risk factors, and treatments. Infection Disease, 53(10), 737-754. doi: 10.1080/23744235.2021.1924397

Ziauddeen, N., Gurdasani, D., O’Hara, M. E., Hastie, C., Roderick, P., You, G., & Alwan, N. A. (2022). Characteristics and impact of Long Covid finding from an online survey. Plos One, 17(3), e0264331. PMID: 34308300

Downloads

Published

2022-06-30

Issue

Section

Research articles