The efficacy of acne gel containing Allium ascalonicum L. extracts

Abstract

The purpose of this study was to study the bioactivity of shallot extract (Allium ascalonicum L.) and to test the efficacy of shallot gel products. Shallots were extracted with 50% ethanol and dried by freeze-dry method. The extracts were then tested for antioxidant activity, anti-tyrosinase activity, and Propionibacterium acnes inhibition. Then, shallot extract was developed as an acne gel and tested for its efficacy against P. acnes bacteria. The results of the study found that shallot extract showed antioxidant activity with half inhibitory concentration (IC₅₀) of 17.04 ± 3.77 µg/mL. The anti-tyrosinase activity test showed that shallot extract had anti-tyrosinase activity with an IC₅₀ of 35.81±1.53 µg/mL. In addition, shallot extract had P. acnes inhibitory activity with the minimum inhibitory concentration (MIC) at 25.00 mg/mL and the minimum bactericidal concentration (MBC) at 50.00 mg/mL. It was then developed into acne gel at concentrations of 0.25, 0.50 and 1.00%. It was found that the gel had antibacterial activity against P. acnes and the shallot gel product had good stability after the heating cooling cycle test. This study is considered to be great benefit to the development of knowledge of Thai traditional medicine and herbal products.