Anti-Advanced Glycation End-products (AGEs) and -Glucosidase Activities of ThaiFolk Anti-Diabetes Remedy

Abstract

Advanced glycation endproducts (AGEs) are formed when blood sugar levels remain high, leading to a variety of complications. Inhibiting the glycation process can be a viable alternative to prevent these complications. The objective of this study was to study the inhibitory effect of advanced glycation end products. and a-glucosidase of six diabetic Thai medicinal formulas extracted by decoction method and macerated with 90% EtOH. The study found that of TFD-02 extracted by decoction method, it has good efficacy in inhibiting the formation AGEs form 7-28 days when compared with aminoguanidine with statistical significance P<0.05, while TFD-04 extracted by decoction method has a-glucosidase inhibitory activity (maltase and sucrase) with IC₅₀ values of 40.46±0.02 and 0.78±0.04 mg/ml, respectively, when compared with acarbose with statistical significance (P< 0.05). The IC₅₀ was 0.59±0.02 and 1.59±0.02 respectively. Based on the results of this study, it demonstrates the potential Thai folk remedies for anti-diabetes, which are suitable for future research and development of herbal products for treatment of diabetes and its complications.