Dopamine for the Treatment of Acute Renal Failure in Leptospirosis
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Abstract
Background: Acute renal failure is the common complication in leptospirosis. Low-dose dopamine is widely used in clinical practice for treating acute renal failure in sepsis from various causes. There are no sufficient evidences in previous literatures to support benefit in routine use of low- dose dopamine. This study was conducted in particular for sepsis from leptospirosis.
Objective: To compare the renal outcomes and other complications between low-dose dopamine and control standard treatment group in leptospirosis.
Method: A randomized clinical trial was conducted. Sixty-nine leptospirosis patients with serum creatinine 2-8 mg/dl were randomized to receive low-dose dopamine or control group in combination with standard treatment for leptospirosis.
Result: The two groups of patients had similar clinical and hematologic characteristics. Peak serum creatinine in the low-dose dopamine group was similar to control group (5.51 ± 2.89 vs 5.39 ± 2.96 mg/dl, p = 0.87). There were not different between both groups in rate of reduction in serum creatinine level (1.078 ± 0.78 vs 0.69 ± 0.69 mg/dl/day, p = 0.064), need for diaiytic therapy (13.3% vs 9.67%, p = 0.408) and length of hospital stay {7.75 ± 4.48 days vs 6.19 ± 3.83 days, p = 0.226).
Conclusion: No significant differences were observed for the renal outcome as peak serum creatinine, rate of reduction in serum creatinine level, need for diaiytic therapy and length of hospital stay between the low-dose dopamine and control group.
Key words: Dopamine. Acute renal failure. Leptospirosis.
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References
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