Comparison of Oral and Intravenous Diazepam for Alcohol Withdrawal Treatment
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Abstract
Background : The prevalence of Alcohol-related problems reported by WHO is 1.7 %. เท Thailand, the survey in 2013 by Mental health department reported 28.5 %.patient admitted in hospital has Alcohol dependence about 20-50 %. About 23 percent of patient admitted in Psychiatric ward, SurinHospital got Alcohol withdrawal symptoms. Alcohol withdrawal may worsen clinical outcomes such as increase infection rate, respiratory failure and prolong hospital stay. ln Alcohol detoxification guideline, benzodiazepine can be given oral or intravenous form. But in clinical observation, patient who receives intravenous has decreases in AWS earlier and shorter hospital length stay than oral form.The objective of this study is to compare efficacy between Intravenous and Oral form of Diazepam in Alcohol withdrawal treatment.
Methods : Randomized single blinded control trial. Sample of this study is the patient who admitted in Psychiatric ward with Alcohol withdrawal symptoms during 1st September 2019 to 28th February 2020. Calculated sample size is 46, random by computer program and sealed envelope. 23 of sample received intravenous Diazepam and 23 received oral Diazepam. The dosage given by AWS evaluation. The interested outcomes were duration received Diazepam (days), accumulation dose (mg.), TMSE and adverse effects.
Results : Intravenous group has 1.3 days that need to given diazepam less than oral group (p=0.001). The accumulations dose of Intravenous group is 62.2 mg. compared with 95.5 mg. of Oral group but not reach statistical difference.There is no statistical difference in TMSE and Side effect for both groups.
Conclusion : In Alcohol detoxification, Intravenous form of diazepam better than Oral form in term of decrease withdrawal symptoms .
Keyword : diazepam, alcohol withdrawal
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References
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