Retrospective analysis of Bone Union Rates in Closed Tibial Shaft Fractures (AO Classification 42A,42B,42C) Following Vitamin D2 and Calcium Supplementation During Post-operative Treatment
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Abstract
Background: While vitamin D and calcium have been shown to promote bone union in osteoporosis patients, there is controversy surrounding their effectiveness in accelerating union rates after operative treatment for closed tibial shaft fractures.
Objective: To compare the union rates between two groups of patients with closed tibial shaft fractures undergoing operative fixation: one group receiving vitamin D2 and calcium supplements (Group 2) and a control group without supplementation (Group 1).
Methods: A retrospective cohort study was conducted using electronic medical records from Surin Hospital for patients treated for closed tibial shaft fractures between January 1st., 2012, and November 30th., 2022. The primary outcome was the union rate, which was compared between two groups: those receiving vitamin D2 and calcium supplements and those who did not.
Results: A total of 202 patients met the inclusion criteria. One hundred nineteen patients did not receive vitamin D2 and calcium supplements (Group 1), while 83 patients received vitamin D2 and calcium at 1,000 mg (Group 2) post-operative fracture fixation. The union rate in Group 1 and Group 2 was 85.7% and 84.3%, respectively.
Conclusion: In patients with closed tibial shaft fractures undergoing operative fixation, there was no statistically significant difference in union rates between those who received vitamin D2 and calcium supplements and those who did not.
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