The Clinical Success of Theracal LC Compared to Calcium Hydroxide for Dental Pulp Capping: A Meta-analysis
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Abstract
Background: The development of 4th generation calcium silicate base materials with added resin, commercially known as Theracal LC®, aims to make pulp capping procedures easier.
Objective: To compare the clinical and radiographic success rates of pulp capping using Theracal LC® versus calcium hydroxide, with a follow-up period of no less than 6 months.
Methods: A systematic search was conducted using PubMed database, along with searches in open access databases and Google Scholar, supplemented by manual searching. Only English or Thai articles published between 2004 and 2024 were included. Nine articles were accepted and used for meta-analysis. The collected data included mean values and standard deviations of success rates for clinical and radiographic outcomes after pulp capping, with patient follow-up periods of 6 months or longer. Relative risk (RR) with 95% confidence intervals were calculated.
Results: A total of 9 articles were analyzed. Theracal LC® showed a higher number of teeth with successful clinical outcomes in pulp capping compared to calcium hydroxide, but the difference was not statistically significant (RR = 1.02, 95% CI 0.99-1.04, p=0.87). The data showed high homogeneity (I²=0.0%), though the number of studies was insufficient.
Conclusion: Theracal LC® demonstrated a higher number of teeth with successful clinical outcomes in pulp capping compared to calcium hydroxide, but the difference was not statistically significant.
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References
Komabayashi T, Zhu Q, Eberhart R, Imai Y. Current status of direct pulp-capping materials for permanent teeth. Dent Mater J 2016;35(1):1-12. doi: 10.4012/dmj.2015-013.
Arandi NZ, Rabi T. TheraCal LC: From Biochemical and Bioactive Properties to Clinical Applications. Int J Dent 2018;2018:3484653. doi: 10.1155/2018/3484653.
İnci MA, Korkut E. Is Bioactive Glass an Effective Agent in Pulp-capping Treatments?: A Randomized Controlled Clinical Trial with One-year Follow-up. J Contemp Dent Pract 2022;23(11):1128-35. doi: 10.5005/jp-journals-10024-3428.
Bhatt RA, Patel MC, Bhatt R, Patel C, Joshi KR, Makwani D. A comparative evaluation of light cure calcium silicate and resin-modified glass ionomer as indirect pulp capping agent in primary molars: A randomized clinical trial. Dent Res J (Isfahan) 2023;20:18. doi: 10.4103/1735-3327.369620.
Manaspon C, Jongwannasiri C, Chumprasert S, Sa-Ard-Iam N, Mahanonda R, Pavasant P, et al. Human dental pulp stem cell responses to different dental pulp capping materials. BMC Oral Health 2021;21(1):209. doi: 10.1186/s12903-021-01544-w.
Cengiz E, Yilmaz HG. Efficacy of Erbium, Chromium-doped:Yttrium, Scandium, Gallium, and Garnet Laser Irradiation Combined with Resin-based Tricalcium Silicate and Calcium Hydroxide on Direct Pulp Capping: A Randomized Clinical Trial. J Endod 2016;42(3):351-5.
doi: 10.1016/j.joen.2015.11.015.
Peskersoy C, Lukarcanin J, Turkun M. Efficacy of different calcium silicate materials as pulp-capping agents: Randomized clinical trial. J Dent Sci 2021;16(2):723-31. doi: 10.1016/j.jds.2020.08.016.
Rahman B, Goswami M. Comparative Evaluation of Indirect Pulp Therapy in Young Permanent Teeth using Biodentine and Theracal: A Randomized Clinical Trial. J Clin Pediatr Dent 2021;45(3):158-64. doi: 10.17796/1053-4625-45.3.3.
Nie E, Yu J, Jiang R, Liu X, Li X, Islam R, et al. Effectiveness of Direct Pulp Capping Bioactive Materials in Dentin Regeneration: A Systematic Review. Materials (Basel) 2021;14(22):6811. doi: 10.3390/ma14226811.
Argueta-Figueroa L, Jurado CA, Torres-Rosas R, Bautista-Hernández MA, Alhotan A, Nurrohman H. Clinical Efficacy of Biomimetic Bioactive Biomaterials for Dental Pulp Capping: A Systematic Review and Meta-Analysis. Biomimetics (Basel) 2022;7(4):211. doi: 10.3390/biomimetics7040211.
Gurcan AT, Seymen F. Clinical and radiographic evaluation of indirect pulp capping with three different materials: a 2-year follow-up study. Eur J Paediatr Dent 2019;20(2):105-10. doi: 10.23804/ejpd.2019.20.02.04.
Mahapatra J, Nikhade P, Patel A, Taori P, Relan K. Comparative Evaluation of the Efficacy of Light-Cured Calcium Hydroxide and a Fourth-Generation Calcium Silicate Cement (TheraCal LC) as Indirect Pulp Capping Materials in Patients With Deep Carious Lesions: A Randomized Parallel-Group Clinical Trial. Cureus 2022;14(9):e28882. doi: 10.7759/cureus.28882.
Betamar N. Evaluation of the Success Rate of Indirect pulp cappingTreatment using Different Materials: A Clinical Study. SJUOB 2022;33(2):203-10. DOI: https://doi.org/10.37376/sjuob.v33i2.7
Jha S, Namdev R, Singhal R, Goel N, Singhal P, Rani R. Comparative Evaluation of Effectiveness of TheraCal LC, MTA, and Calcium Hydroxide in Direct Pulp Capping in Primary Molars: Randomized Clinical Study. Int J Clin Pediatr Dent 2023;16(Suppl 2):213-9. doi: 10.5005/jp-journals-10005-2642.
Semprum-Clavier A, Rodriguez A, Salazar D, Afshari F, Manzotti A, Saleh-Hassan L, et al. Clinical Comparison of Three Indirect Pulp Capping Restorative Protocols: A Randomized Controlled Prospective Study. Oper Dent 2024;49(1):11-9. doi: 10.2341/22-094-C.
Ricucci D, Rôças IN, Alves FRF, Cabello PH, Siqueira JF Jr. Outcome of Direct Pulp Capping Using Calcium Hydroxide: A Long-term Retrospective Study. J Endod 2023;49(1):45-54. doi: 10.1016/j.joen.2022.11.005.