Factors Relating to Locally Advanced Breast Cancer in Rural Areas.
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Abstract
Background: Locally advanced breast cancer (LABC) is high incidence in rural areas especially in northeast part of Thailand. LABC remains a major clinical problem and the prognosis is poor.
Objective: The goals of this study needed to find the factors that relating to LABC and plan for created a proper strategy to reduce the incidence of LABC.
Methods: A study design was a prospective cohort observational study conducted at Surin hospital from January 2020 to January 2022. New cases of breast cancer patients were approached and interviewed before treatment, observed during treatment and followed 1 year after diagnosed.
Results: 141 patients were diagnosed with breast cancer and 20 patients were excluded. A total of 121 patients were approached, the mean age at diagnosed was 52.9 years. At presentation 46.3 % (95%CI 37.2%, 55.6%) of breast cancer patients were locally advanced stage. The factors relating to LABC were duration of symptoms before treatment (p < 0.001), nulliparity (p = 0.037), tumor grade (p = 0.026) and presence of angiolymphatic invasion (p = 0.022). 1- year survival in LABC is less than early breast cancer significantly (82.1% vs 100%, p < 0.001).
Conclusion: Prolonged duration of symptoms before treatment, nulliparity, high tumor grade and presence of angiolymphatic invasion were factors relating to locally advanced breast cancer in rural areas. The proper strategy to reduced duration of symptoms before treatment may decrease the incidence of LABC in rural areas.
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References
Virani S, Bilheem S, Chansaard W, Chitapanarux I, Daoprasert K, Khuanchana S, et al. National and Subnational Population-Based Incidence of Cancer in Thailand: Assessing Cancers with the Highest Burdens. Cancers (Basel) 2017;9(8):108. doi: 10.3390/cancers9080108.
American Cancer Society. Breast Cancer Facts & Figures 2017-2018. Atlanta : American Cancer Society, Inc. ; 2017.
Unger-Saldaña K. Challenges to the early diagnosis and treatment of breast cancer in developing countries. World J Clin Oncol 2014;5(3):465-77. doi: 10.5306/wjco.v5.i3.465.
Gueye M, Gueye S, Diallo M, Thiam O, Mbodji A, Diouf A, et al. Sociodemographic Factors Associated with Delays in Breast Cancer. Open J Obstet Gynecol 2017;7(4):455-63. doi: 10.4236/ojog.2017.74047.
Čačala SR, Gilart J. Factors Relating to Late Presentation of Patients With Breast Cancer in Area 2 KwaZulu-Natal, South Africa. J Glob Oncol 2017;3(5):497-501. doi: 10.1200/JGO.2016.008060.
Ibrahim NA, Oludara MA. Socio-demographic factors and reasons associated with delay in breast cancer presentation: a study in Nigerian women. Breast 2012;21(3):416-8. doi: 10.1016/j.breast.2012.02.006.
Espina C, McKenzie F, Dos-Santos-Silva I. Delayed presentation and diagnosis of breast cancer in African women: a systematic review. Ann Epidemiol 2017;27(10):659-671.e7. doi: 10.1016/j.annepidem.2017.09.007.
Virani S, Chindaprasirt J, Wirasorn K, Sookprasert A, Somintara O, Vachirodom D, et al.
Breast Cancer Incidence Trends and Projections in Northeastern Thailand. J Epidemiol 2018;28(7):323-330. doi: 10.2188/jea.JE20170045.
Garg PK, Prakash G. Current definition of locally advanced breast cancer. Curr Oncol 2015;22(5):e409-10. doi: 10.3747/co.22.2697.
Newman LA. Epidemiology of locally advanced breast cancer. Semin Radiat Oncol 2009;19(4):195-203. doi: 10.1016/j.semradonc.2009.05.003.
Aebi S, Karlsson P, Wapnir IL. Locally advanced breast cancer. Breast 2022;62 Suppl 1(Suppl 1):S58-S62. doi: 10.1016/j.breast.2021.12.011.
Tesfaw A, Tiruneh M, Tamire T, Yosef T. Factors associated with advanced-stage diagnosis of breast cancer in north-west Ethiopia: a cross-sectional study. Ecancermedicalscience 2021;15:1214. doi: 10.3332/ecancer.2021.1214.
Dhanushkodi M, Sridevi V, Shanta V, Rama R, Swaminathan R, Selvaluxmy G, et al.
Locally Advanced Breast Cancer (LABC): Real-World Outcome of Patients From Cancer Institute, Chennai. JCO Glob Oncol 2021;7:767-81. doi: 10.1200/GO.21.00001.
Klein J, Tran W, Watkins E, Vesprini D, Wright FC, Look Hong NJ, et al. Locally advanced breast cancer treated with neoadjuvant chemotherapy and adjuvant radiotherapy: a retrospective cohort analysis. BMC Cancer 2019;19(1):306. doi: 10.1186/s12885-019-5499-2.
Singh AS, Bhardwaj BS, Goswami BC. Disease free survival in locally advanced breast cancer: An analysis of clinical and pathological factors. Asian Pac J Cancer 2022;7(1):21-7. DOI:10.31557/APJCC.2022.7.1.21
Kuhn E, Gambini D, Despini L, Asnaghi D, Runza L, Ferrero S. Updates on Lymphovascular Invasion in Breast Cancer. Biomedicines 2023;11(3):968. doi: 10.3390/biomedicines11030968.
Tan EY, Wong HB, Ang BK, Chan MY. Locally advanced and metastatic breast cancer in a tertiary hospital. Ann Acad Med Singap 2005;34(10):595-601. PMID: 16382243
