Impact of Diabetes, Obesity or excessive weight gain on birthweight and pregnancy outcomes, retrospective study in BMA General hospital
Main Article Content
Abstract
Objective: To study the association between diabetic with or without excessive weight gain and
birthweight.
Method: Retrospective study of 577 pregnant women who labourat BMA general hospital and between
18-35 years old were divided to 4 groups; normal weight gains pregnancy group, obesity or excessive weight
gain pregnancy group, gestational diabetes mellitus (GDM) group and both conditions in pregnancy group.
Result: Five hundred and seventy-seven pregnancies were enrolled. Maternal age, BMI, excessive
weight gain in 4 groups were difference significantly. Average birth weight in each groups were 3,027 3,274
3,210 3,438 grams respectively, were difference significantly (p<0.01). Use logistic regression revealed
that excessive weight gain group had 5 times increase risk to have macrosomia compare with normal weight
gain pregnancy group. DM group was significantly associated with increased risk to occur birth asphyxia,
hypertension and cesarean section (p<0.01). Postpartum hemorrhage was no difference between 4 groups.
Conclusion: The significant risk factor associated with macrosomia was excessive weight during pregnancy.
GDM was associated with birth asphyxia, hypertension and cesarean section.
Key word: Gestational diabetes mellitus, fetal macrosomia, excessive weight gain.
Article Details
References
India J med Res 2013; 137: 728-733.
2. ธีระ ทองสง. โรคเบาหวานในสตรีตั้งครรภ์.ใน:ธีระ ทองสง,สุชยา ลือวรรณ, บรรณาธิการ. สูติศาสตร์ เรียบเรียง. พิมพ์ครั้งที่ 5.
ปทุมธานี: PB FORBOOK xm6,Tkou. sohk 425-38.
3. Triunfo S, Lanzone A. Impact of overweight and
obesity on obstetric outcomes. Journal of
Endocrinological investigation 2014; 37: 323-9.
4. Lao TT1, Wong KY. Perinatal outcome in large-
for-gestational-age infants. Is it influenced by
gestational impaired glucose tolerance?. J Reprod
Med 2002; 47: 497-502.
5. Casay BM, Lucas MJ. Pregnancy outcomes in
women with gestational diabetes compared with
the general obstetric population. Obstet Gynecol
1997; 90: 869-73.
6. Jensen MD. Obesity. In: Goldman L, Schafer
th
AI, editors. Goldmanûs Cecil Medicine. 24 ed.
Philadelphia, PA: Saunders Elsevier 2011; chap
227.
7. American College of Obstetricians and
Gynecologists. Committee Opinion No.549:
Obesity in pregnancy. Obstet Gynecol 2013; 121:
213-7.
8. Lashen H, Fear K, Sturdee DW. Obesity is
associated with increased risk of first trimester
and recurrent miscarriage: matched case-control
study. Hum Reprod 2004; 19: 1644-6.
9. Baeten JM, Bukusi EA, Lambe M. Pregnancy
complications and outcomes among overweight
and obese nulliparous women. Am J Public Health
2001; 91: 436-40.
10. Cedergren MI. Maternal morbid obesity and the
risk of adverse pregnancy outcome. Obstet
Gynecol. 2004; 103: 219-24.†
11. Cnattingius S, Bergstrom R, Lipworth L, Kramer
MS. Prepregnancy weight and the risk of adverse
pregnancy outcomes. N Engl J Med 1998; 338:
147-52.†
12. Oken E, Taveras EM, Kleinman KP, Rich-Edwards
JW, Gillman MW. Gestational weight gain and
child adiposity at age 3 years. Am J Obstet
Gynecol 2007; 196: 322.e1-8.
13. American College of Obstetricians and
Gynecologists. Fetal macrosomia. ACOG Practice
Bulletin 22. Washington, DC: ACOG; 2000.
14. American College of Obstetricians and
Gynecologists. Committee Opinion No.548:
Weight gain during pregnancy. Obstet Gynecol
2013; 121: 210-2.
15. Crane JM, White J, Murphy P. The effect of
gestational weight gain by body mass index on
maternal and neonatal outcomes. J Obstet
Gynaecol Can 2009; 31: 28-35.
16. Marin J.A., Russu M., Hudita D, Nastasia S.
Diabetes, Obesity and Excessive weight gain and
Pregnancy outcomes. Timisoara Medical Journal
2009; 59: 184-7.
17. Chow S, Shao J, Wang H. Sample Size
Calculations in Clinical Research. 2nd ed.
Chapman & Hall/CRC Biostatistics Series 2008;
p.100.