Mitochondrial Myopathy, Encephalopathy, Lactic acidosis, and Stroke-like Episodes (MELAS): A case report
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Abstract
In this report, we discussed a case of a 14 year-old girl who presented with recurrent seizures 4 times in 3 months. The diagnosis on her first admission in Buriram hospital was viral encephalitis. The sequential changes of her brain Computed tomography (CT) and Magnetic resonance imaging (MRI) are the clue to definite diagnosis. Further molecular study, a typical for MELAS syndrome mutation was found. The rarity of this disorder and the complexity of its clinical presentation make MELAS patients among the most difficult to diagnose. The most helpful investigations to confirm diagnosis are the MRI and Magnetic resonance spectroscopy (MRS). We would like to describe characteristic radiological features of MELAS syndrome in CT, MRI and MRS of the brain and differential diagnosis.
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