Risk Factors and Characteristics of Hepatocellular Carcinoma in SurinHospital : A Retrospective study
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Abstract
Background: Hepatocellular carcinoma is becoming a significant health problem in Thailand. Major risk factors are alcoholic liver disease, HBV infection and HCV infection. Surin province has the third most cancer patients of Northeastern Thailand and liver cancer is the leading cause of cancer. Therefore, studying of characteristics, clinical presentation and treatment of hepatocellular carcinoma patients can lead to greater understanding and make a better plan of management.
Objective: To study characteristics, risk factors, clinical presentation, treatment and gender influence of hepatocellular carcinoma patients in Surin hospital.
Setting: Surin Hospital
Study design: Descriptive retrospective study
Methods: Review data of both out-patient and in-patient department patients who were diagnosed of hepatocellular carcinoma (ICD10 - C22.0) during 1 October 2010 to 30 September 2011.
Results: The study revealed the data of 83 patients, 68 males (81.9%) and 15 females (18.1%). The means of age were 59.3 (±11.0) years, albumin 2.8 (±0.7) g/dL.The median of total bilirubin 1.5 mg/dL, AST 117U/L, ALT 54 U/L, AP 189U/L and creatinine 1.0 mg/dL. Most of patients were related to alcohol consumption (38 patients, 59.4%), HBV infection (21 patients, 52.5%) and HCV infection (4 patients, 10%).The median AFP was 257 IU/L. Mean of the largest mass was 9.6 (±4.3) cm. and most of them were located at right lobe of liver (45 patients,75%). Diagnostic imaging, CT scan was used in 37 patients (52.1%), US 29 patients (40.8%) and MRI 5 patients (7%). About the treatment, almost patients received supportive treatment (65 patients, 78.3%). Finally, gender between male and female was neither relate in clinical nor laboratory features of hepatocellular carcinoma.
Conclusions: Major risk factors of hepatocellular carcinoma in Surin hospital are alcohol consumption and HBV infection. Large single mass is the most radiological finding and usually located at right lobe of liver. Gender is not relate to clinical and laboratory features of hepatocellular carcinoma in this study.
Keywords: hepatocellular carcinoma, AFP
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