Postoperative Analgesic Effect of Preoperative Parecoxib after Total Abdominal Hysterectomy
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Abstract
Objective: To evaluate the effect of preoperative parecoxib (40 mg.) on postoperativepain after total abdominal hysterectomy
Research design: Randomized controlled trial (RCT)
Setting: Operation room and Gynecologic ward at surin hospital
subject: Sixty women with age 18-55 years, ASA physical status 1-2scheduledfortotal abdominal hysterectomy at operation room, Surin Hospital
Method: Sixty women scheduled for elective total abdominal hysterectomy undergeneral anesthesia, were randomized to receive intravenous parecoxib 40mg. or placebo 30 minutes before operation and then 12 hours later. Doses of morphine for 24 hours and side effect were recorded.Painscorewereassessed at 4, 8, 12, 24 hours after operation.
Statistical analysis: Independent t-test, Chi-square test
Result: The total morphine requirement in the first 24 hours of parecoxib group (8.5mg.) was significantly less than control group (11.3 mg.). VNRS of parecoxib group was significantly lower than control group at 4, 8, 12 hours postop¬erative. Fewer patient in parecoxib group experienced postoperative nausea and vomiting (10 versus 19, p=0.039).
Conclusion: Parecoxib provided a lower pain and lesser morphine consumption after total abdominal hysterectomy with significantly less nausea and vomiting
Key words: Parecoxib, postoperative analgesia, total abdominal hysterectomy (TAH)
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References
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