Discordant Immunological and Virological Responses to Antiretroviral Therapy in Surin hospital
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Abstract
Background: The pathogenesis of discordant responses between absolute CD4 count and viral load is unclear, this seems to depend on the interaction of a multitude of viral, host and treatment-related factors. Available evidence indicates that discordant responses are associated with an intermediate risk of death or clinical progression. At present, recommendations for the clinical management of patients with discordant responses to antiretroviral therapy are largely based on observational uncontrolled data.
Objective: To determine the discordant immunological and virological responses to antiretroviral therapy at Surin hospital.
Study design: Action Research
Result: Data to allow meaningful comparisons between studies to be made, as well as to help in the design of trials of possible therapeutic interventions. In this study, immune discordance was found 8%, treatment failure 5%, viral discordance 10% and treatment response 77%.
Conclusion: Number of HIV infected person and AIDS disease progression associated with treatment response in different area.
Key words: Discordant responses, absolute CD4+ count, viral load
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References
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