Effect of Hemoglobin E disorder on Hemoglobin Aic in Diabetic patients

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Published: Oct 30, 2018
Keywords:
Diabetes mellitus Hemoglobinopathy Hemoglobin A1 (HbA)

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Passorn Sueyunyongsiri
Departments of Internal Medicine, Surin Hospital, Surin, Thailand

Abstract

Objective: This research aims to study effect of hemoglobin E disorder on hemoglobin A1c (HbA1c) level of diabetic patients in Surin hospital.
Methods: A retrospective study was conducted from 2006 to 2007. Patient's profile, blood glucose and HbA1c level were collected and divided in hemoglobin E disorder group and control group. Each sample arm was classified into seven subgroups according to blood glucose level to compare HbA1c level in each subgroup.
Results: During 2006-2007, 28 diabetic patients with hemoglobin E disorder were found from overall 910 diabetic patients. There is no difference of sex  average age and blood glucose between hemoglobin E disorder and control group. Patients with hemoglobin E disorder had lower HbA1c level than those of control group (P<0.001).
Conclusion: Since HbA1c levels is presently the best indicator of long term glycemic control. With similar fasting glucose, hemoglobin E disorder is associated with lower HbAlc level.
Key words: Diabetes mellitus, Hemoglobinopathy, Hemoglobin A1 (HbA)

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How to Cite
Sueyunyongsiri, P. (2018). Effect of Hemoglobin E disorder on Hemoglobin Aic in Diabetic patients. MEDICAL JOURNAL OF SISAKET SURIN BURIRAM HOSPITALS, 23(2), 637–643. retrieved from https://he02.tci-thaijo.org/index.php/MJSSBH/article/view/152112
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Vol. 23 No. 2 (2008): May - August 2008
Section
Original Articles

References

1. Menon RK & Sperling MA. Childhood diabetes. Med. Clinics North Am. 1988;41:1565-75.

2. Burin HF, Haney DN, Kamin S, Gabbaj KH, Gallop PM. The biosynthesis of human hemoglobin Aj . J. Clin. Invest. 1976;41:1652-9.

3. Fitzgibbons JF, Koler RD, Jones RT. Red-cell age-related changes of hemoglobins AIa+b and AIc in normal and diabetic subjects. J Clin Invest. 1976;(58)4:820-4.

4. Mayer TK & Freedman ZR. Protein glycosylation in diabetes mellitus : A review of laboratory measurements and of their clinical utility. Clin. Chim. Acta 1983;41:147-84.

5. Weykamp CW, Penders 17, Muskiet FAJ, Slik W. Influence of hemoglobin variants and derivatives on glycohemoglobin determinations, as investigated by 102 laboratories using 16 methods. Clin. Chem. 1993;41:1717-22.

6. Krzisnik C & Lukac-Bajalo J. Glycosylated hemoglobin in fractions of erythrocytes of different ages. J. Endocrinol. Invest. 1993;41:495-8.

7. Fucharoen S, Winichagoon P. Problems of Thalassemia in Thailand. ICMR annals. 8(1988);29-33.

8. Martina WV, Martijn EG, van der Molen M, Schermer JG, Muskiet FAJ. B-N- terminal glycohemoglobins in subjects with common hemoglobinopathies : relation with fructosamine and mean erythrocyte age. Clin Chem 1993;39:2259-65.

9. Weykamp CW, Penders TJ, Muskiet FAJ, van der Slik W. Influence of hemoglobin variants and derivatives on glycohemoglobin determinations, as investigated by 102 laboratories using 16 methods. Clin Chem 1993;39:1717-23.

10. Miedema K. Influence of Hemoglobin Variants on the Determination of Glycated hemoglobin. Klin Lab 1993;39:1029-32.

11. P.lefebvre, Diabetes yesterday, today and tomorrow. The action of the Internation Diabetes Federation, Rev. Med. Liege 60(2005);273-7.

12. J.L. Camargo and J.L. Gross, Glycohemo­globin : clinical and analytical aspects, Arq. Bras. Endocrinol. Metabol. 48(2004);451-63.

13. T. Lahousen, R.E. Roller, R.W. Lipp and W.J. Schnedl, Determination of glycated hemoglobins (HbA1c), Wien Klin Wochenschr. 2002;114(8-9);301-5.

14. M. Tominaga and Hemoglobin A1c (HbA1c), Nippon Rinsho 60 (Suppl.8) (2002);405-9.