Comparison of Propofol and Propofol plus small dose ketamine
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Abstract
Objective: To evaluate and compare the effectiveness and side effects amongs propofol, propofol plus ketamine in outpatient anesthesia
Research design: Randomized controlled trial (RCT)
Setting: Obstetrics operation room in Surin hospital
Subjects: Forty - two females with age 16 - 50 years for minor operation
Method: Forty - two females were randomly allocated to receive Fentanyl 1 (ig./kg. plus propofol 2 mg./kg. IV in group I (n=21) or Fentanyl 1 (ig./kg. plus propofol 1 mg./kg. plus ketamine 0.5 mg./kg. IV in group II (n=21) Patient were evaluated in terms of quality of anesthesia, cardio pulmonary stability, recovery profile and post operative complication
Result: Compared with patients in group 1, patients in group 2 had a significantly cardiovascular stability, less oxygen supplement, and none of them required supplemental anesthetic drug. When comparing the recovery from anesthesia, the time to discharge in group 1 (99.10 + 23.12) was significantly shorter than in group 2 (131.43 + 30.92) they also had fewer side effect, (nausea, vomiting, vertigo and headache)
Conclusion: The addition of ketamine (0.5 mg./kg) to propofol (1 mg./kg) provided hemodynamic stability, less respiratory depression and decresesd anesthetic requirement but delay in discharge times. However, propofol - ketamine can be used as an alternative effective anesthetic technique.
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References
2. Suzuki M, Tsuesa K, Lansing PS, et al. Small - dose ketamine enhances morphine - induced analgesia after outpatient surgery. Anesth analg 1999;89:98-103.
3. Mortero RF, Clark LD, Tolan MM et al. The effects of small - dose ketamine on propofol sedation : respiration, postoperative mood, perception cognition, and pain. Anesth Analg 2001;92:1465-9.
4. Pauthawang Kun J, Santati - anan J, Lertakyamanee J, et al. Local lidocaine, propofol and ketamine for anesthesia in cystoscopy. Thai Journal of Anesthesiology 1997;23:113-22.
5. Hare RA, Mirakhur RK, Reid JE, et al. Recovery from propofol anesthesia supplemented with remifentanil. Br J Anaesth 2001;86:361-5.
6. Jenkins K, Grady D, Wong J, et al. Post operative recovery: day surgery patients’ preferences, Br. J Anaesth 2001;86:272-4.
7. Badrinath S, Avranor MN, Shadrick M, et al. The use of a ketamine -propofol combination during monitored anesthesia care. Anesth Analg 2000;90:858-62.
8. Freg K, Sukhani R, Pawlowski J, et al. Propofol versus propofol ketamine sedation for retrobulbar nerve block : comparison of sedation quality, intraocular pressure changes, and recovery profiles. Anesth Analg 1999;89:317-21.
9. Guignard B, Coste C, Costes H, et al. Supplementing desflurane - remifentanil anesthesia with small - dose ketamine reduces perioperative opoid analgesic requirements. Anesth Analg 2002;95:103-8.
10. Reeves M, Lindholm DE, Myles PS, et al. Adding ketamine to morphine for patient-controlled analgesia after major abdominal surgery : A double-blinded, randomized controlled trial. Anesth Analg 2001;93:116-20.
