Placenta Percreta and Methotrexate Treatment : A Case Report
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Abstract
Placenta percreta is a potential life-threatening condition. The detection of placenta percretain the first trimester is rare. However, the physicians should have suspicion in case of incomplete abortion with predisposing factors, such as history of cesarean section. The conventional treatment of placenta percreta is hysterectomy. The conservative treatment, like methotrexate (MTX) remains alternative when patients have inactive bleeding and desire to preserve the fertility.
This case report examines a 26-year-old woman, at 12 weeks of gestation with a history of previous cesarean section, was referred for further management for incomplete abortion. The transvaginal ultrasonography (TVUS) and magnetic resonance imaging (MRI) confirmed the diagnosis of placenta percreta. MTX was administrated weekly for 3 weeks. The β-hCG gradually decreased to a normal level and ultimate resolution of placenta percreta from TVUS was observed at 3 months after treatment.
Keywords: Placenta percreta, methotrexate, Thailand
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References
Breen JL, Neubecker R, Gregori CA, Franklin JE Jr. Placenta accreta, increta, and percreta. A survey of 40 cases. Obstet Gynecol 1977;49(1):43-7.
Fox H. Placenta accreta, 1945-1969. Obstet Gynecol Surv 1972;27:475-90.
Wang YL, Weng SS, Huang WC. First-trimester abortion complicated with placenta accreta: A systematic review. Taiwan J Obstet Gynecol 2019;58(1):10-14. doi: 10.1016/j.tjog.2018.11.032.
Shah J, Matta E, Acosta F, Golardi N, Wallace-Huff C. Placenta Percreta in First Trimester after Multiple Rounds of Failed Medical Management for a Missed Abortion. Case Rep Obstet Gynecol 2017;2017:6070732. doi: 10.1155/2017/6070732.
D'Antonio F, Timor-Tritsch IE, Palacios-Jaraquemada J, Monteagudo A, Buca D, Forlani F, et al. First-trimester detection of abnormally invasive placenta in high-risk women: systematic review and meta-analysis. Ultrasound Obstet Gynecol 2018;51(2):176-183. doi: 10.1002/uog.18840.
D'Antonio F, Iacovella C, Palacios-Jaraquemada J, Bruno CH, Manzoli L, Bhide A. Prenatal identification of invasive placentation using magnetic resonance imaging: systematic review and meta-analysis. Ultrasound Obstet Gynecol 2014;44(1):8-16. doi: 10.1002/uog.13327.
Singh BY, Raghav V, Kapur A. Medical Management of Placenta Accreta with Methotrexate: Review of Two Cases. J SAFOG 2015;7:86-8.
Mussalli GM, Shah J, Berck DJ, Elimian A, Tejani N, Manning FA. Placenta accreta and methotrexate therapy: three case reports. J Perinatol 2000;20(5):331-4. doi: 10.1038/sj.jp.7200373.
Arulkumaran S, Ng CSA, Ingemarsson I, Ratnam SS. Medical treatment of placenta accreta with methotrexate. Acta Obstet Gynecol Scand 1986;65(3):285-6. doi: 10.3109/00016348609155187.
Heiskanen N, Kröger J, Kainulainen S, Heinonen S. Placenta percreta: methotrexate treatment and MRI findings. Am J Perinatol 2008;25(2):91-2. doi: 10.1055/s-2007-1004831.
Tong SY, Tay KH, Kwek YC. Conservative management of placenta accreta: review of three cases. Singapore Med J 2008;49(6):e156-9.
Chou MM, Yuan JC, Lu YA, Chuang SW. Successful treatment of placenta accreta spectrum disorder using management strategy of serial uterine artery embolization combined with standard weekly and a 8-day methotrexate/folinic acid regimens at 7 weeks of gestation. Taiwan J Obstet Gynecol 2020;59(6):952-955. doi: 10.1016/j.tjog.2020.09.027.
Halal HA, Shammary MA, Tawfeeq T, Mahmmoud S, Jabari AA. Conservative management of abnormal placenta accrete complicating the first trimester abortion: A casereport and review of literature. Open J Clin Med Case Rep 2019;5:1-11.