Preoperative Norgesic® Prevent Succinylcholine-induced Myalgia in Postoperative Pain: The Double-blind Randomized, Placebo-controlled Trial
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Abstract
Background: Postoperative myalgia is one of the common side effects from fasciculation when patients received succinylcholine. Norgesic® has muscle relaxant effect from Orphenadrine therefore we assume that pretreatment with Norgesic® can reduce injuries from muscle spasm and painful muscular symptom.
Objective: To compare incidenceof postoperative myalgia in 24 hours between patients received preoperative Norgesic® and placebo. The primary outcome was the incidence of postoperative myalgia in 24 hours. The secondary outcome was severity of myalgia at 1,6, 24 hours postoperative.
Methods: This is a prospective randomized double blinded controlled study. 60patients undergoing general anesthesia using succinylcholine for intubation were randomized into two groups (n=30 each). Group[NOR] received Norgesic® 2 hours before operation, and Group[PLA] received placebo. Data on baseline characteristics, incidence of myalgia and postoperative pain scores on numeric rating scale at 1,6 and 24 hours after operation, the need to analgesic for myalgia(paracetamol) and surgical pain(morphine), and adverse effect of Norgesic® were collected. Student’s t-test, chi-squared test were used.
Results: A total 60 patients were included in the analysis. The Norgesic® group had a significant lower postoperative myalgia (26.7% vs 73.3%; p=0.001) at 24 hours post-operative. There was no statistically significant difference in the activity of daily living(ADL)disturbance, drug’s side effect and total rescue pain medication consumption.
Conclusion: Preoperative with Norgesic® 2 hour prior to operation decrease the incidence of postoperative succinylcholine related myalgia.
Keywords: succinylcholine, postoperative myalgia, Norgesic, prevention
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References
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