Accuracy of FNA in Diagnosis of Thyroid Nodule
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Abstract
Background: Thyroid nodule is a common endocrine disorder. Screening diagnostic procedure is fine needle aspiration (FNA), and the result of this test is important for the treatment planning.
Objective: To study sensitivity, specificity and accuracy of FNA for diagnosis of thyroid cancer.
Methods: This retrospective cross-sectional study was conducted on 1,137 patients with thyroid nodules who underwent FNA and tissue biopsy at Maharat Nakhon Ratchasima Hospital from Jan 1st, 2019 to Dec 31st, 2019. The prevalence was reported as a percentage classifying in age group, sex, nodular location, nodular size and thyroid hormone status. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate of FNA were analyzed using pathology as the reference standard.
Results: Thyroid cancer was found in 62 cases from 1,137 cases. According to FNA T1-T2 was negative group and T3-T6 was positive group, the sensitivity was 75.4% (95%CI 62.7-85.5), the specificity was 82.3% (95%CI 79.8-84.5), the positive predictive value was 19.4% (95%CI 14.6-25.0), the negative predictive value was 98.3% (95%CI 97.3-99.1) and the accuracy was 81.8% (95%CI 79.5-84.0).
Conclusion: FNA is a reliable method for diagnosis of thyroid cancer. Patients with T3-T6 increase risk of malignancy and should be proceeded to appropriate surgical procedures.
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