Formulation and Stability of Developed Taste and Smell 1.0% Povidine Mouthwash

Abstract

Background: Povidine mouthwash can reduce Covid-19 virus in mouth cavity. However, the cost is high (5.97 bath/ml) and povidine has bad smell, taste and poor stability. Therefore, we developed 1.0% povidine mouthwash formular with separate vehicle to extend the age of the solution.
Objectives: To develop flavour and study stability of 1.0% povidine mouthwash. Furthermore, to compare cost(price) and satisfactions between the developed taste and smell 1.0% povidine mouthwash and the dilution with water of 1.0% povidine mouthwash.
Methods: Developed smell and taste of povidine mouthwash; Studied stability by analyzing remained iodine from faculty of Pharmaceutical Science, Ubon Ratchathani University(standard range 85.0-120.0% of 0.10% iodine). In addition, compared cost(price) and satisfactions of 11 dentists and 30 patients between the dilution with water of 1.0% povidine mouthwash(No.1) and developed taste and smell 1.0% povidine mouthwash(No.2), use single-blind method, exclusion critera: thyroid dysfunction, pregnancy, lactation, kidney disease, children under 6 years old or allergy to iodine. Descriptive statistics and spearman rank test were used.
Results: Developed taste and smell of 1.0% povidine mouthwash formular which was included vehicle that composed of glycerine 3.0 ml, 70.0% sorbitol 4.5 ml, strawberry flavor 0.45 ml water qs to 30.0 ml, and 10.0% povidine 3.33 ml in amber bottle(mix by pour the vehicle into povidine bottle). Remained iodine at 0, 4, 8, 36, 56 hours after mixed at 28.0(±2.0) oC were 98.0(±0.0), 96.0(±0.0), 93.0(±0.0), 92.0(±0.0), 89.0(±0.2), 86.0(±0.0), respectively. The cost (price) of No.1 and No.2 are 0.34(0.44) and 0.53(0.67) bath/ml, consequently. Satisfactions of dentists and patients in No.1 were 2.5(±0.5) (low), 3.3(±1.0) (moderate) and in No.2 were 3.1(±0.9) (moderate), 3.4(±0.8) (moderate), respectively. (using Likert-Type-Scale)
Conclusion: Developed taste and smell 1.0% povidine mouthwash (No.2) was stable 56 hours and cheaper than 1.0% povidine mouthwash in the market; Moreover, satisfactions of dentists and patients in developed taste and smell 1.0% povidine mouthwash were more than the dilution with water of 1.0% povidine mouthwash(No.1).