Fetal Nasal Bone Length by Three-dimensional Ultrasound in High Risk Thai Pregnant Women during 16 to 21 weeks’ Gestation at Buri Ram Hospital
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Abstract
Background: Down syndrome (DS) is the common cause of chromosomal anomalies in newborns. One of the most useful DS screening methods is second trimester ultrasound (US) examination. Among many ultrasound markers, short nasal bone length (NBL) which defined as the fifth percentile of NBL reference range is the powerful US marker for DS screening. Using three-dimensional (3D) US can help easier acquired mid-sagittal plane for NBL measurement.
Objective: To generate reference range of fetal three-dimensional nasal bone length (NBL) at 16 to 21 weeks’ gestation in Thai high risk pregnancies.
Methods: A prospective, cross-sectional study in Thai high risk pregnant women was conducted at 16 to 21 weeks’ gestation. NBL was collected by 3D US. The ultrasound was performed by one operators (maternal fetal medicine (MFM) staff). Intraclass correlation coefficient was used to calculate for intra-observer. Regression analysis was used to determine the association between NBL and gestational age (GA). Reference ranges of NBL were represented by percentile values.
Results: 196 high risk pregnant women are included. Linear correlation was observed between NBL and GA (NBL (mm) = -9.91672 + 0.11076xGA (days); R2 0.82). The fifth percentile of NBL were 2.11 mm at 16 weeks and increased to 5.69 mm at 21 weeks.
Conclusions: NBL were increased with gestational age during 16 to 21 weeks of gestation in Thai high risk pregnant women. When compare to two-dimensional US, NBL measured from 3D US is shorter.
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References
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