Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio in the Diagnosis of Neonatal Sepsis Debaratana Hospital Nakhon Ratchasima Province
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Abstract
Background: Neonatal sepsis is a leading cause of death and complications in neonates. Diagnosing neonatal sepsis is based on history, physical examination, and laboratory test results. Therefore, there should be appropriate parameters help to diagnosis the occurrence of neonatal sepsis.
Objective: To investigate the Diagnostic ability of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in neonatal sepsis at Debaratana Hospital in Nakhon Ratchasima Province.
Methods: This retrospective diagnostic study examines the NLR and PLR values in early onset neonatal sepsis and treated at Debaratana Hospital in Nakhon Ratchasima Province between October 1st 2019, and September 30th 2022, containing 183 cases. The data were analyzed using diagnostic tests to determine sensitivity, specificity, and the area under the ROC curve.
Results: A total of 183 neonates participated in the study, including 158 infants with suspected early onset neonatal sepsis and 25 infants with provened early onset neonatal sepsis. The optimal neutrophil-to-lymphocyte ratio (NLR) cutoff point was determined to be 3.015, showing a sensitivity of 48.0%, specificity of 61.4%, and an area under the ROC curve of 0.547 (95% CI: 0.440–0.654). For the platelet-to-lymphocyte ratio (PLR), the optimal cutoff point was 74.795, demonstrating a sensitivity of 40.0%, specificity of 62.0%, and an area under the ROC curve of 0.510 (95% CI: 0.405–0.615).
Conclusion: The values for area under the curve of NLR and PLR are still not reliable. These values are not helpful for the diagnosis of early onset neonatal sepsis. The study methods should be reviewed, and additional information should be collected.
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