Prevalence and Associated Factors of Cognitive Impairment in Major Depressive Disorders
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Abstract
Background: Cognitive impairment is commonly found in major depressive disorders and is associated with deficits in psychosocial functioning, leading to long-term disability even after remission of depressive symptoms. This impairment is a key factor contributing to social and occupational dysfunction in affected patients.
Objective: To study prevalence and factors associated of cognitive impairment in patients with depressive disorder.
Methods: It was a cross-sectional study. The sample consisted of 140 outpatients with depressive disorder. The assessment tools were composed of 4 parts: demographic questionnaire, Medical information questionnaire, Depressive Assessment (9Q) and The Montreal Cognitive Assessment: MoCA Thai Version (version 0.1). The data was analyzed by descriptive statistics, Pearson’s Chi-Square test and Logistic regression analysis. Statistical significance was set at the 0.05 level.
Results: The prevalence of cognitive impairment in depressive patients was 56.4%. The protective factor associated with cognitive impairment was education level from high school, vocational certificate and high vocational certificated (adj OR = 0.08, 95%CI = 0.01, 0.46), bachelor's degree or above (adj OR = 0.05, 95%CI = 0.00, 0.52). The risk factors were marital status with marriage (adj OR = 10.35, 95%CI = 2.62, 40.94) and receiving antipsychotic medication for treatment (adj OR = 4.64, 95%CI = 1.50, 14.32).
Conclusions: The finding of this study could deliver fundamental data to develop care guideline for depressive patients with cognitive impairment in Thailand for getting the most out of patients, families and society, which was important driving force of the nation.
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