A Cohort Study of Impact of Surgery Types on Recurrence and Metastasis of Breast Cancer in the Young
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Abstract
Introduction: Aim of this study is to compare the outcomes of modified radical mastectomy (MRM) and breast conservative therapy BCT about local recurrence and distance metastasis, factors associated with local recurrence and distance metastasis and survival rate in young breast cancer equal or less than 35 years old
Methods: The retrospective cohort study was conducted during January 2010 to December 2019 Buri Ram Hospital. All patients equal or less than 35 years old who underwent MRM BCT were included but patients with coexists cancer were excluded.
Results: Sixty-seven patients equal or less than 35 years old were diagnosed with breast cancer The meanage (Mean± SD) was 31.9±3. 1years. The operative treatments were MRM cases (65.5%) and BCT 23 cases (35.4%). There was no statistically difference according to local recurrence and distant metastasis between two groups (P= 0.625). In MRM group, tumor grade I, small tumor size, T stage 1-2, and small numbers o flymphnode metastases were demonstrate dinno local recurrence and distant metastas is patients. In BCT group, larger tumor size had high local recurrence and metastas is (P=0.036). The median survival time was 86 months in MRM group and 67 months in BCT group respectively (HR 1.29, 95% C.I. 0.54-3.07, P = 0.554)
Conclusions: The outcome of recurrence, metastasis and survival not different between MRM and BCT. The larger tumor in BCT group had higher recurrence and metastasis rate. Pathological finding was considered before surgery for good surgical outcome.
Keywords: Modified radical mastectomy, Breast conservative therapy, Breast cancer in young, Metastasis, Local recurrence
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