Comparison of Microbilirubin Reduction Rate Treated by Phototherapy in Neonatal Hemolytic Versus Nonhemolytic Jaundice

Abstract

Background: Neonatal jaundice is a common problem in newborn. Phototherapy is one of the safest and effective methods of treatment.It has been widely used for a long time. Hemolytic jaundice is one of the factors that affect the effectiveness of treatment. In 2004, the American Academy of Pediatrics suggested hemolysis disease was assessed as one of the major risk factors with the potential to cause severe jaundice and resulting in reduced treatment efficiency. Consider using lower bilirubin levels than other groups to initiate treatment. The objective was to compare the effectiveness of phototherapy in infants between hemolytic and nonhemolytic jaundice. Evaluated from the reduction rate of microbilirubin.
Methods: Retrospective study, newborns with jaundice treated by phototherapy From January 1 - December 31, 2020, total of 345 cases were reviewed by medical records were collected and evaluated the effectiveness of phototherapy by use the reduction rate of microbilirubin. Using mean, median, standard deviation (SD),Exact probability test, t-test, univariable regression, multivariate regression
Results: The effectiveness of phototherapy treatment in neonatal jaundice. There was no statistically significant difference between hemolytic vsnonhemolytic jaundice. The median of reduction rate of microbilirubin per hour after phototherapy treatment between groups with hemolysis vsnonhemolysis, 1stevaluated 0.9, 1.2 (p-value 0.14), 2nd evaluated 1.3, 1.4 (p-value 0.95), 3rd evaluated No. 3 0.9, 1.0 (p-value 0.62)and 4th evaluated –0.001, 1.0 (p-value 0.60), respectively.
Conclusion: Bilirubin levels had the greatest reduction in the first 24-48 hours after phototherapy. The pathogenetic factors of the disease did not affect the effectiveness of treatment.
Keywords: Neonatal hemolytic jaundice, microbilirubin reduction rate, effectiveness of phototherapy