Mortality Rate and Factor Associated Mortality in Extremely Low Birth Weight Infants in Sunpasitthiprasong Hospital
Article Sidebar
Main Article Content
Abstract
Background: Extremely low birth weight (ELBW) infants are high risk for mortalities and morbidities. Identifying of risk factors associated mortality provides information on improving health outcomes.
Objective: To determine mortality rate, factor associated mortality and comorbidities of ELBW infants.
Methods: Medical records of all ELBW infants at Sunpasitthiprasong Hospital during 2016-2022 were collected. Antenatal history, perinatal data and neonatal outcome until hospital discharge were extracted and analyzed.
Results: There were 253 ELBW infants with 48.6% mortality. The three most frequent comorbidities including respiratory distress syndrome (85.8%), neonatal sepsis (53%) and PDA (48.2%). Factors as birth weight less than 750 grams, preeclampsia, no antenatal steroid administration, Apgar score at 5 minute less than 7, air leak syndrome requiring drainage, intubation longer than 7 days and requirement of oxygen therapy longer than 28 days were associated with mortality.
Conclusion: This study demonstrates mortality rate of ELBW infants was 48.6%. There were several factors associated mortality. Better health outcomes require strategies to prevent and manage these complications.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Eichenwald EC. Extremely low birth weight infants. In: Gleason CA, Juul SE, editors. Avery's Diseases of the Newborn. 10th ed. Philadelphia : Elsevier ; 2018 : 390-404.
Ramaswamy VV, Abiramalatha T, Bandyopadhyay T, Shaik NB, Bandiya P, Nanda D, et al. ELBW and ELGAN outcomes in developing nations-Systematic review and meta-analysis. PLoS One 2021;16(8):e0255352. doi: 10.1371/journal.pone.0255352.
Bell EF, Hintz SR, Hansen NI, Bann CM, Wyckoff MH, DeMauro SB, et al. Mortality, In-Hospital Morbidity, Care Practices, and 2-Year Outcomes for Extremely Preterm Infants in the US, 2013-2018. JAMA 2022;327(3):248-63. doi: 10.1001/jama.2021.23580.
Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics 2010;126(3):443-56. doi: 10.1542/peds.2009-2959.
Isayama T, Lee SK, Mori R, Kusuda S, Fujimura M, Ye XY, et al. Comparison of mortality and morbidity of very low birth weight infants between Canada and Japan. Pediatrics 2012;130(4):e957-65. doi: 10.1542/peds.2012-0336.
Su BH, Hsieh WS, Hsu CH, Chang JH, Lien R, Lin CH, et al. Neonatal outcomes of extremely preterm infants from taiwan: comparison with Canada, Japan, and the USA. Pediatr Neonatol 2015;56(1):46-52. doi: 10.1016/j.pedneo.2014.05.002.
พิมลรัตน์ ไทยธรรมยานนท์, สันติ ปุณณะหิตานนท์. ภาวะแทรกซ้อนและการเสียชีวิตของทารกแรกเกิดน้ำหนักน้อยมากในโรงพยาบาลจุฬาลงกรณ์. จุฬาลงกรณ์เวชสาร 2551;52(4):255-64.
Kiatchoosakun P, Jirapradittha J, Paopongsawan P, Techasatian L, Lumbiganon P, Thepsuthammarat K, et al. Mortality and Comorbidities in Extremely Low Birth Weight Thai Infants: A Nationwide Data Analysis. Children (Basel) 2022;9(12):1825. doi: 10.3390/children9121825.
Martin RJ, Fanaroff AA, Walsh MC, editors. Fanaroff and Martin's Neonatal-Perinatal Medicine, Diseases of the Fetus and Infant. 11th ed. Philadelphia : Elsevier ; 2020.
Polin RA, Yoder MC, editors. Workbook in Practical Neonatology. 6th ed. St. Louis, MO : Elsevier ; 2020.
Wayne WD. Biostatistics: a foundation of analysis in the health sciences. 8th ed. New York : Wiley ; 2005.
ชมพูนุท สมานชาติ. อัตราการรอดชีวิตและปัจจัยที่มีผลต่อการรอดชีวิตของทารกแรกเกิดที่น้ำหนักแรกเกิดน้อยกว่า 1,000 กรัม ในโรงพยาบาลศรีสะเกษ. วารสารการแพทย์โรงพยาบาลศรีสะเกษ สุรินทร์ บุรีรัมย์ 2564;36(2):265-74.
ภิญญดา แก้วปลั่ง. อัตราการรอดชีวิตและปัจจัยเสี่ยงต่อการเสียชีวิตของทารกแรกเกิดน้ำหนักน้อยมากในโรงพยาบาลสุรินทร์. วารสารการแพทย์โรงพยาบาลศรีสะเกษ สุรินทร์ บุรีรัมย์ 2554;26(3):379-92.
พิมล วงศ์ศิริเดช, วัชรี ตันติประภา. Perinatal and Neonatal Palliative Care. ใน: วินัดดา ปิยะศิลป์, วันดี นิงสานนท์, บรรณาธิการ. Pediatric Palliative Care. พิมพ์ครั้งที่ 1. กรุงเทพฯ : เพนตากอน แอ็ดเวอร์ไทซิ่ง ; 2558 : 157-68.
Moya F, Javier MC.Myth: all surfactants are alike. Semin Fetal Neonatal Med 2011;16(5):269-74. doi: 10.1016/j.siny.2011.03.006.
Singh N, Halliday HL, Stevens TP, Suresh G, Soll R, Rojas-Reyes MX. Comparison of animal-derived surfactants for the prevention and treatment of respiratory distress syndrome in preterm infants. Cochrane Database Syst Rev 2015;2015(12):CD010249. doi: 10.1002/14651858.CD010249.pub2.
Miyazawa T, Arahori H, Ohnishi S, Shoji H, Matsumoto A, Wada YS, et al. Mortality and morbidity of extremely low birth weight infants in Japan, 2015. Pediatr Int 2023;65(1):e15493. doi: 10.1111/ped.15493.
Adams-Chapman I, Hansen NI, Stoll BJ, Higgins R; NICHD Research Network . Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertion. Pediatrics 2008;121(5):e1167-77. doi: 10.1542/peds.2007-0423.
Yucel OE, Eraydin B, Niyaz L, Terzi O. Incidence and risk factors for retinopathy of prematurity in premature, extremely low birth weight and extremely low gestational age infants. BMC Ophthalmol 2022;22(1):367. doi: 10.1186/s12886-022-02591-9.
Chatziioannidis I, Mitsiakos G, Karagianni P, Tsakalidis C, Dimopoulou A. Predictors of early neonatal mortality in extremely low birth weight infants in a Neonatal Intensive Care Unit over a 10-year period. J Pediatr Neonat Individual Med 2020;9(1):e090115. https://doi.org/10.7363/090115
Roberts D, Brown J, Medley N, Dalziel SR. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 2017;3(3):CD004454. doi: 10.1002/14651858.CD004454
Ehret DEY, Edwards EM, Greenberg LT, Bernstein IM, Buzas JS, Soll RF, ET AL. Association of Antenatal Steroid Exposure With Survival Among Infants Receiving Postnatal Life Support at 22 to 25 Weeks' Gestation. JAMA Netw Open 2018;1(6):e183235. doi: 10.1001/jamanetworkopen.2018.3235.
Haumont D, Modi N, Saugstad OD, Antetere R, NguyenBa C, Turner M, et al. Evaluating preterm care across Europe using the eNewborn European Network database. Pediatr Res 2020;88(3):484-95. doi: 10.1038/s41390-020-0769-x.
Asztalos EV, Murphy KE, Willan AR, Matthews SG, Ohlsson A, Saigal S, et al. Multiple courses of antenatal corticosteroids for preterm birth study: outcomes in children at 5 years of age (MACS-5). JAMA Pediatr 2013;167(12):1102-10. doi: 10.1001/jamapediatrics.2013.2764.
Abo El Naga AM, Hafez MO, El Bana EA, Shehata AMI. Study of Some Predictors of Neonatal Mortality among Preterm Newborn at Zagazig University Hospital. Egypt J Hosp Med 2022;88(1):2677-82. DOI: 10.21608/EJHM.2022.241116
Castro EC, Leite ÁJ, Guinsburg R. [Mortality in the first 24h of very low birth weight preterm infants in the Northeast of Brazil]. [Article in Portuguese]. Rev Paul Pediatr 2016;34(1):106-13. doi: 10.1016/j.rpped.2015.08.011.
Aziz K, Lee HC, Escobedo MB, Hoover AV, Kamath-Rayne BD, Kapadia VS, et al. Part 5: Neonatal Resuscitation: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2020;142(16_suppl_2):S524-S550. doi: 10.1161/CIR.0000000000000902.
Choi YB, Lee J, Park J, Jun YH. Impact of Prolonged Mechanical Ventilation in Very Low Birth Weight Infants: Results From a National Cohort Study. J Pediatr 2018;194:34-39.e3. doi: 10.1016/j.jpeds.2017.10.042.
Wai KC, Kohn MA, Ballard RA, Truog WE, Black DM, Asselin JM, et al. Early Cumulative Supplemental Oxygen Predicts Bronchopulmonary Dysplasia in High Risk Extremely Low Gestational Age Newborns. J Pediatr 2016;177:97-102.e2. doi: 10.1016/j.jpeds.2016.06.079.
