Comparison between Aspirin plus Clopidogrel Versus Aspirin Alone in Patients with Acute Ischemic Stroke or High Risk Transient Ischemic Attack for Prevention of Recurrent Ischemic Stroke in Pakchongnana Hospital: a retrospective study
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Abstract
Background: Acute minor ischemic stroke and high risk transient ischemic has a risk of developing acute recurrent stroke in 90 days equal to 8.4 percent. A previous study found that taking antiplatelet drugs, aspirin and clopidogrel, reduced the chance of recurring acute ischemic stroke by 20 percent compared to taking aspirin alone.
Objective: To study the effects of using aspirin in conjunction with clopidogrel, compare with aspirin alone in acute minor ischemic stroke and high risk TIA patients.
Methods: Retrospective cohort study, from recording of patients with acute minor ischemic stroke and high risk TIA in Pakchongnana hospital. 200 people divided into 2 groups. Data from 100 patients were collected between October 2020 and May 2021 for the aspirin-clopidogrel group, while data from another 100 patients were recorded from January 2019 to December 2020 for the aspirin-only group, with both groups being monitored for a period of 90 days. Data analysis using descriptive statistics, the chi-square test, and the odds ratio using Chi-square test statistics
Results: Recurrent acute ischemic stroke in 90 days between aspirin combined with lopidogrel occurred in 3 patients (3 percent) compared to the dose received aspirin alone occurred in 5 patients (5 percent) (odd ratio, 1.63; confidence interval (CI), 0.20 to 13.49; P=0.36) and no occurred hemorrhagic stroke in 90 days between groups receiving aspirin with clopidogrel compared to the group receiving aspirin alone.
Conclusions: In the study involving patients with minor ischemic stroke or high risk TIA, those who received a combination of aspirin and clopidogrel had a similar risk of recurrent ischemic stroke compared to those who received aspirin alone. Furthermore, the combination therapy showed no increased risk of hemorrhage at the 90-day mark. Therefore, from such data, The management of these patients using either single or dual antiplatelet regimens has been found to exhibit comparable efficacy and side effect profiles.
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References
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