Correlation of Breast Imaging and Pathological Subtype of Young Breast Cancer Under 35 Years Old
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Abstract
Introduction: The aim of this study is correlated the mammography and ultrasonography with pathological finding in young breast cancer under 35 years old.
Methods: Retrospective review was made of all patients under 35 years old who diagnosis breast cancer at Buri Ram Hospital between January 2014 and December 2019. Mammography and ultrasonography were performed together with pathological finding and immunohistochemistry (IHC) were reported.
Conclusion: Forty-nine patients under 35 years old were diagnosis breast cancer. The mean age was 31.5years. Breast cancer subtype was divided to luminal A nine patients (18.4%), luminal B twenty-nine patients (59.2%), Human epidermal growth factor receptor2 (HER2) overexpression one patient (2%) and triple negative breast cancer (TNBC) ten patients (20.4%). Fine pleomorphic calcification was 58.4% which associated with axillary lymph node metastasis (p-value 0.029). Hypoechoic mass and shadowing of posterior feature were correlated with high grade tumor. Lymphadenopathy which found from mammography was associated with luminal A (p-value 0.034). Vascularity mass was found in HER2 over expression 57.1% (p-value 0.001).
Results: The imaging finding of breast cancer especially the patient under 35 years old could be predict the pathological finding and breast cancer subtype including high grade tumor, lymph node metastasis, Luminal A and HER2 over expression.
Keywords: Mammography, ultrasonography, young breast cancer, pathology, immunohistochemistry.
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References
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