Paracetamol for Peri-operative Anesthesia Care

Kanittha  Chongwilaiwan; Pattharaporn  Sombood; Tuanlutfee  Tuwanhayee; Phongthara  Vichitvejpaisal

Authors

Kanittha Chongwilaiwan Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Pattharaporn Sombood Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Tuanlutfee Tuwanhayee Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Phongthara Vichitvejpaisal Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand

Keywords:

acetaminophen, multimodal analgesia, pain management, paracetamol, peri-operative anesthesia care

Abstract

This review encapsulates paracetamol’s pharmacokinetics, pharmacodynamics, and pharmacogenomics. Preclinical and experimental evidence underscores paracetamol’s unique analgesic effects, examining animal models, dose-response relationships, and its influence on inflammatory and nociceptive pathways. In the clinical realm, paracetamol emerges as a cornerstone of multimodal analgesia, targeting peri-operative pain challenges. This article explores paracetamol’s role in diverse surgical contexts, and in special patient populations. Notably, paracetamol’s ability to reduce opioid consumption while preserving effective pain control is examined, alongside its impact on post-operative outcomes and patient satisfaction.

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