Complete Blood Count Markers of Infection in Anti-interferon-γ Autoantibody-Associated Immunodeficiency with Reactive Dermatoses:

Chudapa Sereeaphinan; Penvadee Pattanaprichakul; Sumanas Bunyaratavej; Pattriya Jirawattanadon; Nasikarn Angkasekwinai; Weerapat Owattanapanich; Charussri Leeyaphan

doi:10.33192/smj.v78i7.280076

Authors

Chudapa Sereeaphinan Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Penvadee Pattanaprichakul Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Sumanas Bunyaratavej Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Pattriya Jirawattanadon Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Nasikarn Angkasekwinai Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Weerapat Owattanapanich Division of Hematology, Department of Internal Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Charussri Leeyaphan Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

DOI:

https://doi.org/10.33192/smj.v78i7.280076

Keywords:

Adult-onset immunodeficiency syndrome, anti–interferon-gamma autoantibodies, reactive dermatoses, concurrent infection

Abstract

Objective: To identify clinical and laboratory parameters associated with infections in patients with reactive dermatoses.

Materials and Methods: This retrospective study reviewed the medical records of patients diagnosed with adult onset
immunodeficiency syndrome caused by anti-interferon-gamma autoantibodies. Clinical data, laboratory findings, and information on concurrent infections were analyzed.

Results: Of the 147 patients reviewed, 62 (42.2%) presented with reactive dermatoses, accounting for 135 episodes. Patients with concurrent infections had significantly lower mean corpuscular volume (78.5 vs. 84.9 fL; p=0.039). In contrast, red cell distribution width (16.2 vs. 14.1%; p=0.005), white blood cell count (20.96 vs. 15.56 ×103/μL; p=0.037), absolute neutrophil count (15.76 vs. 11.14 ×103/μL; p=0.038), and platelet count (414.5 vs. 376.0 ×103/μL; p=0.023), were significantly higher in infected episodes than in non-infected episodes.

Conclusion: In patients presenting with reactive dermatoses, laboratory parameters derived from the routine complete blood count can serve as valuable indicators of increased risk for concurrent infections, enabling prompt diagnosis and targeted management.

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